With the increasing popularity of the Windows environment, advent of 32-bit CPUs, a shift in the PC market and increasing popularity of the Internet came the need for a completely different antivirus approach as well. Besides the virus scanning and cleaning functionality it only featured heuristic analysis. Due to the limitations of the OS (lack of multitasking among others) it didn't feature any on-demand/on-access protection nor most of the other features of the current versions.

It was created in 1987 by Miroslav Trnka and Peter Paško at the time when computer viruses started to become increasingly prevalent on PCs running DOS. The first version of NOD32 – called NOD-ICE – was a DOS-based program. The acronym NOD stands for Nemocnica na Okraji Disku ('Hospital at the end of the disk'), a pun related to the Czechoslovak medical drama series Nemocnice na kraji města ( Hospital at the End of the City). The Business Edition packages add ESET Remote Administrator allowing for server deployment and management, mirroring of threat signature database updates and the ability to install on Microsoft Windows Server operating systems. ESET NOD32 Antivirus is sold in two editions, Home Edition and Business Edition. Microsoft Windows, macOS, Linux, FreeBSD, Solaris, Windows Mobile, AndroidĮSET NOD32 Antivirus, commonly known as NOD32, is an antivirus software package made by the Slovak company ESET.

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